Anne (6 February 1665 – 1 August 1714) became Queen of England, Scotland and Ireland on 8 March 1702. On 1 May 1707, under the Acts of Union, two of her realms, the kingdoms of England and Scotland, united as a single sovereign state, the Kingdom of Great Britain. She continued to reign as Queen of Great Britain and Ireland until her death.Anne was born in the reign of her uncle Charles II, who had no legitimate children. Her father, James, was first in line to the throne. His Catholicism was unpopular in England and on Charles's instructions Anne was raised as a Protestant. Three years after he succeeded Charles, James was deposed in the "Glorious Revolution" of 1688. Anne's Protestant brother-in-law and cousin William III became joint monarch with his wife, Anne's elder sister Mary II. Although the sisters had been close, disagreements over Anne's finances, status and choice of acquaintances arose shortly after Mary's accession and they became estranged. William and Mary had no children. After Mary's death in 1694, William continued as sole monarch until he was succeeded by Anne upon his death in 1702.As queen, Anne favoured moderate Tory politicians, who were more likely to share her Anglican religious views than their opponents, the Whigs. The Whigs grew more powerful during the course of the War of the Spanish Succession, until in 1710 Anne dismissed many of them from office. Her close friendship with Sarah Churchill, Duchess of Marlborough, turned sour as the result of political differences.Anne was plagued by ill-health throughout her life. From her 30s onwards, she grew increasingly lame and corpulent. Despite seventeen pregnancies by her husband, Prince George of Denmark, she died without any surviving children and was the last monarch of the House of Stuart. Under the terms of the Act of Settlement 1701, she was succeeded by her second cousin George I of the House of Hanover, who was a descendant of the Stuarts through his maternal grandmother, Elizabeth, daughter of James VI and I.